ISSN 0976 044X
Research Article minocycline IMPROVES MEMORY IN MORRIS WATER MAZE TASK IN INTRACEREBROVENTRICULAR STREPTOZOTOCIN INFUSED RATS
Vivek Kumar Sharma1* and Ashok Kumar Goyal2 * Govt. College of Pharmacy, Rohru, Dist. Shimla-171207, Himachal Pradesh,India 2 Onkar College of Pharmacy, Sunam, Dist. Sangrur, Punjab, India *Corresponding authors E-mail: viveksharma_pharma@yahoo.co.in
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receive on: 21-10-2010; Finalized on: 14-12-2010.
ABSTRACT In the register study, the aftermath of minocycline was studied against intracerebroventricular streptozotocin generate spatial store deficit. manful wistar rats were injected with intracerebroventricular streptozotocin bilaterally. The rats were treated chronically with Minocycline (10, 20 and 40 mg/kg, ip) for 17 days starting from day 1 of streptozotocin gibe in separate groups. The spatial memory was evaluated using the Morris wet maze task. The intracerebroventricular streptozotocin infused rats showed significant memory deficits and minocycline showed significant dose dependent improvement in the task.
The study demonstrated the effectualness of minocycline in preventing spatial memory deficit induced by streptozotocin and its potential in age related neurodegenerative dis hunting lodges where memory impairment is involved such as Alzheimers disease. Keywords: Minocycline, spatial memory, ICV streptozotocin rats, Morris water maze.
INTRODUCTION Alzheimers disease (AD) is a advancing neurodegenerative disorder with a mean duration of around 8.5 old age between onset of clinical symptoms and death1. AD is the most vernacular cause of dementia in the elderly population. The most widely used treatment for Alzheimers disease at present are acetylcholinesterase inhibitors, which aim to prolong normal cognitive process through increased synaptic activity, without providing neuroprotection. This treatment is only characteristic and provides modest outcomes...If you want to get a full essay, order it on our website: Ordercustompaper.com
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